Wow, so I bought Guitar Hero: Aerosmith after renting it about six months ago. My old score was 120k on Train Kept A Rollin... One attempt six months later, and I scored 340k, and I was more or less sightreading the chart after not playing it for so long.
In that six month space, all I played was Rock Band/Rock Band 2. The tighter timing window really, really helped -- The hammer-ons in this game were so loose and relaxed in comparison.
Basically, star power the chords, practice the trills if you can't hit them, you want to break combo as little times as possible. If you miss a starpower phrase before the drum roll, restart the song. In fact, if you miss a star power phrase that you're sure you can usually hit (ie. you choked) then restart and go again. The SP phrases are invaluable.
Most proud completion: IKARUGA - 200/200
on x360a (and first in Australia, according to MGC.net) to complete Green Day: Rock Band
on x360a (and first in Australia, according to MGC.net) to complete Dance Central