I love this game, but the most common and infuriating gliche I encountered was boss battles where the boss character repeated the same moves over and over again without exposing their weakness. First time it happened was on Hammerhead. After restarting the battle, he fell easily, following his pattern right through.
Happened again a few times, noticeably on Mysterio, where was convinced he was invincible until it occurred to me to restart the battle and see if it was stuffing up again. Turns out it was. :/