You certainly want to play through this game twice.
Get all collectibles, upgrade weapons, learn enemies' fighting style & weaknesses, and earn the other miscellaneous achievements.
Just fly through the game. Only do that which is necessary to advance the story line. Hit the BACK button to skip cutscenes. It will still take 3-4 hours to complete, but you can do it.
Enemies are tougher, but you know how to handle them with your fully upgraded weapons and knowledge.
I'm offering this advice to confirm the guide suggestion to play through twice.
ALICE: MADNESS RETURNS 900G, Feb 13th 2012