A few I've come across is in the mission where you kidnap STAG cover boy and when you pick him up the screen goes black but you can hear sound, had to quit out and do that again. Also I bring my pistol out to a ped and they just runaway, what happened to mugging? Lastly half the time when I try to enter a vehicle via jumping through the windows (duke style) sometimes it doesn't work, I know you sprint up then press Y cuz I already have the achievement but the feature has been iffy for me since the start.
Now this ain't a glitch but I must say the graphics on the game suck at major standards.
His name be Francis