Couple of things so far:
Bioware needs to hire some fucking animators that didn't just get out of DigiPen. Raising team members puts people in their default "T" poses for a minute, rendering them useless until they pick up some AI commands.
Sometimes I lose my helmet in the vacuum of space. It's cool. I get it back in the middle of combat.
A shooter oriented RPG that won't let me fine tune stick sensitivity? Really?
I like how people in group conversations will step in, say a few words, and then back away from the group. Like, all the time. So unnatural.
I had to watch Anderson run again. That was fun.
Audio pops occasionally. It's usually from explosions, but only when a lot is going on.
I hate that I'm in the opening stages of the game and I'm running in to this stuff.
Oh, and the cover system is a mess. I've been spoiled by Gears of War 3. Sometimes, cover will bug out, and you will have to back a good 3 feet away before being able to take cover. I'm doing insanity right off the bat, so it's caused some very avoidable deaths. Unacceptable.