Originally Posted by scottttocs
you cant miss any of them, and you can do them whenever the hell you want. i'd suggest doing the arena first, you can get some skill leveled up while you're at it. then just go through the guilds from start to end one at a time. then do the main story. all cheevo's are story/guild related and cannot be missed.
EDIT: there is one missable achievement, but it is on the shivering isles, DLC. i dont know if you plan on playing through it(you should, its excellent), but there is a choice to made later on in the main quest of this DLC. i won't spoil it for you, so refer to the guide in the shivering isles sub-forum whne you start the shivering isles.
Thats all I pretty much needed to know, unsure If I'm going to get the DLC yet though. Thanks.