Originally Posted by AscendingSnow
Use pistols on any "hard" enemy, I recommend finding both the dual pistol holster (in the frontier) and the double-barrel pistols (in Boston).
Wolf cloak works (as long as you use the hidden blades), but my choice was the eagle ability (with the hidden blades). fly to a roof, fly down to perform a double-assassination, and repeat the process.
Not even worth using pistols....Calling in your Wolf Pack eliminates 3 of the guards at once, and using Wolf Cloak kills are 25x more useful and faster than Eagle Flight Assassinations.