I'm in the process of doing 1999 Mode right now. It's not that bad, you just need to be careful, take cover, and plan ahead. The only parts that have given me real trouble so far are the Handyman fights and the Siren battles, but they seem to have their own workarounds.
Last Completed Retail: BioShock Infinite
Last Completed Arcade: Sonic the Fighters
Nothing personal, but I do not accept random friend requests.