I didn't encounter many glitches and the ones I did find were quite funny. In the mission where you help Irish save his friend in Thieves' landing and get the Gatling gun I had an experience where after the cutscene where you load up the gun the wagon launched about 50 feet in the air and smashed to the ground and I failed the mission. It was so random I couldn't help but laugh for a good while.
"I thought what I'd do was pretend I was one of those deaf-mutes.
"When you have eliminated the impossible
, whatever remains
, however improbable
, must be the truth.