Just played and finished the game. I don't think the woman watching the camera during the cutscenes is the wife, I think it's the daughter, Mary.
The girl looks a bit young to be the wife and if you look near the camera during her scenes you'll see a stuffed bunny rabbit. That same, or very similar bunny, is shown in the mall on a shelf after you bring Mei the medicine. And it might be the same stuffed animal Mei gives you to give to your daughter.