Can be done with two controllers.
When you are on offense, you have to rush the ball for a touchdown with either your running back or your quarterback. Try to get as close to the end zone as possible and then you can just run a QB Sneak and rush up the middle or you can try an outside run play with your running back. Outside run plays are very easy to get a lot of yards because once you get to the sideline, you can just run up the field and the defenders will most likely not tackle you.
Make sure you get a touchdown with the same player 5 times. A lot of times the game substitutes your second string running back in for your first string so just make sure the starting running back is always in the game when you get a touchdown.