Story related and cannot be missedunless he commits suicide by blasting himself against one of the pillars with his own BFG.
This boss is Sergeant Kelly, but he has become mutated and possessed. A really easy and quick way to kill him is to make sure your Soul Cube is charged before entering the room for the fight and then right when the boss says the word “welcome,” launch the Soul Cube and then fire FIVE rockets and he should die in a few seconds.
You can get the SoulFood achievement here too. Just save before the fight and hit him with the five rockets first THEN finish him with the soul cube. After you have control of your guy again, load the previous save and repeat.
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