Can be bought from the Capsule shop after completing the Adept Championship. From the main menu, go to World Match. Advanced can be very challenging as enemies will try and go for the ring out if you get careless. Advanced has 5 rounds and a 50 000 Zenie reward.
Easy Strategy: choose a custom character to your liking (preferably a small character like Gohan or Krillen. Next equip Viral Heart disease and Vaccine. I personally didn't have vaccine, so I swapped it with a Senzu Bean capsule so that when I died, I would get a free revival with full health. This made it a cakewalk, obviously.
A quick way to end these fights is to get ring outs. Get your opponent near the edge and use a move that pushes them back, such as Kamehameha (,,,), or the running kick or punch (towards twice on the d-pad, then or when you are close) to knock them out. Unfortunately, the AI will try to use this same tactic, so you could block and dodge, wait until Viral Heart Disease has nearly beaten them, then finish them off with a little combo.