Take the lead on lap 1, in heavy rain, after starting in 5th or lower
Set up a Grand Prix at Monza and set the race distance to one lap, with the weather set to heavy rain. Also, make sure to set rules and flags to reduced and select race only in the race distance settings.Select a Ferrari driver, as your chances to start in 5th or lower are considerably higher than with a Red Bull or McLaren driver - in any case, your place on the grid is randomized, so there is a chance that you have to set up the Grand Prix again in order to start from 5th or lower.
As soon as the race starts, use up all of your KERS, making sure to overtake all of the cars before the race leader turns into the first corner and drive straight through the chicane. You will get disqualified for cutting the chicane, but if you do it right you will get the achievement, since the DSQ triggers after you have passed the race leader for first place.
If the achievement does not pop shortly after you get disqualified, simply retry.
Note: The title of this achievement is a homage to Ayrton Senna's first lap at the 1993 European Grand Prix at Donington, considered by many to be the greatest single lap in F1 history as Senna, starting from 4th place and falling back to 5th behind Schumacher right after the start, managed to overtake 4 cars for the lead in heavy rain within 1 minute.
R.I.P Ayrton Senna. What an absolute F1 legend. Seeing as this is an achievement website and not a tribute page, i'll give some advice. Pick a track with a decent size main straight, and use all of the KERS at the start to overtake. It goes without saying that you need to be 5th or lower in the grid.