To begin this quest you will need to find a boy named Bryan Wilks who is usually just outside Grayditch
. He will ask you to find his father in town. Their house is near the diner. Once you find him (dead) report back to Bryan who will most likely now be hiding in the Pulowski Preservation Shelter next to the diner (it is a big metal tube). You tell Bryan that you will stop the ants which will send you to the Marigold Metro Station. Navigate quite a ways until you find a small office with a Dr. Lesko inside. He will tell you about the experiments he is doing and ask you to deal with the situation by killing the ant queen's guards. You can either stop after killing the guards like he asks, or just kill the queen and be done with the situation. Either way you can now report to Bryan that the ants are done. However, Bryan now has no family and no place to live. He will ask you to find his aunt Vera who owns the hotel in Rivet City. Go there and ask he to take Bryan in. She will agree and upon delivering the news to Bryan back in Grayditch you will finish the quest.