Fairly straightforward once again. Just beat Tezzeret in the campaign mode to unlock this achievement. Tezzeret runs a Blue and Black Mana deck.
The Blue deck was really good for countering the million Artifacts he seems to have. You could then use the few flying creatures you have to peck away at his health, but if he has his cards out that lets him tap two lands and get 1 LP each time he does it, just give up.
The white deck worked well. I played him again using the White and Blue decks and won it easier with the White.