This is a story related achievement which will unlock with natural story progression.
Before you attempt this achievement, see "Dogged" before you proceed.
You will need to collect a short knife and a long knife for the experiment. Pick up the first knife on the top row, and the last knife on the bottom.
Take the knives to holmes and give him the large knife. You will now be able to start the experiment. Check the boxes of the following knives on each experiment.