To earn the Master Alchemist Achievement you need to unlock the Mutant Ability found towards the end of the Alchemy Skill Tree. You need 8 talent points in order to unlock the Mutant ability. If you don't want to invest in this skill, make sure you save before you spend the talent points. Then you can go back to your save with the talent points intact. You cannot earn this while playing the arena mode. You can get the "Swordmaster", "Mutant", "Master Alchemist", and "Master of Magic" achievements in one go, by using the From a Bygone Era side mission on Iorveth's path in the correct manner. Follow the walkthrough here.
An easy way to get this acheivement and all the other mastery achievements without using multiple characters. Go to the Operator in Loc Muinne, and save before using him to re-allocate all of your stats. You can get the achievement, than re-load your save, and do that for all of those achievements.
played on dark.. saved all my skill points until chapter 2 had 15 of them...spend in one tree reload save rinse repeat until you have all achievements.. spend the one remaining point on last skill in whatever tree you in to acquire last skill to ad a mutagen to it....done
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