- Estimated achievement difficulty: 4/10 [Achievement Difficulty Rating]
- Offline: 46 
- Approximate amount of time to 1000: 20-25 Hours [Estimated Time to 100%]
- Minimum number of playthroughs needed: 1
- Missable achievements: Many, see below
- Does difficulty affect achievements: N/A
- Unobtainable/glitched achievements: No
As mentioned above, the game has many missable and mutually-exclusive achievements, so you'll want to pay attention to those and save prior to making any story-altering choices to ensure you can get all the options. There is also a specific set of choices to be made to get the "good" ending, so you'll want to make those choices last and continue your save file along with those. See Change the future (70G) for more info on those choices. You'll also need to pay attention to Rena armory (50G) and be sure to upgrade one character's weapon prior to them leaving the party for good.
Outside of that, mostly everything else is story-related, aside from a few specific combat achievements. You will want to work on your defensive parry and offensive critical attacks throughout the game since you need 500 of each. Lastly, for collectibles, you'll want to be sure to collect every treasure chest - though this achievement is a bit glitched in a good way and you only need a set amount of chests, which is cumulative through multiple playthroughs - and you'll need all of the equipment in the game as well, so don't sell anything.
Prior to the final battle, do a run through the achievement list and make sure you've done your 500 parries/criticals, upgraded all weapons, found all chests, obtained all equipment, captures all souls, and killed 20 of each slime type. But again, if you follow the walkthrough, you'll be fine. And that's it. We'll get all the achievements in one run through the use of many save/reload situations, and shouldn't need anything else. If by some accident you miss a treasure chest, start a new game and grab however many you need in a new run. If you missed any of the side-quest or story choice achievements, you'll be in for a whole second playthrough, so do avoid that.