Overview:
-Estimated achievement difficulty: 10/10
-Offline: 46 (1000)
-Online: 0
-Approximate amount of time to 1000: 75-150 Hours
-Minimum number of playthroughs needed: 6
-Number of missable achievements: 0
-Glitched achievements: None!
-Do cheat codes disable achievements?: No Cheats

Devil May Cry 4 is the first game of the series on the 360, and is one of the best action games on it. Veterans of the series will know however, this is a very difficult game to beat, let alone max out. If you are planning on trying to max this game out, be prepared to get your butt kicked, a lot.

Introduction
So, you want to max out Devil May Cry 4 eh? Well, it'll take more then wanting it for it to happen, as this is not an easy 1000. In the Devil May Cry series, insane combos and obscene fighting is the name of the game.

The Devil May Cry series handles fights differently than most games. Instead of just fighting, you are graded by a combo meter mid-fight, going from D to SSS. At the end of each level, you are graded in three categories, Time, Style, and Orbs. The reason why this game is so hard to max out is because of four achievements, which require you to S-rank every mission on each of the four main difficulties. If that wasn't bad enough, the difficulty achievements require a playthrough on every difficulty, as the achievements do not stack.

There are no missable achievements at all in this game, which is a relief. However, the different achievements in this game are just as hard to complete, ranging from grinding, to pain in the ass collection achievements.

On top of the grinding and collections, you also have three more game modes. One of the game modes, Heaven or Hell, is a unique mode in which everyone, including you, die in one hit, with another mode called Hell or Hell which is similar, except you are the only one that dies in one hit. The last game mode is called the Bloody Palace, which requires you to fight several hundred enemies and nearly all the bosses in the game non-stop.

Step #1: Learn the Game
You're going to be playing this game quite a few times, so take the time to learn the in's and out's and to learn the level layouts. Your first playthrough of the game should be focused on improving your character by maxing out your health and devil trigger bars. On top of this, you should also start stocking up on items scattered throughout each level. So start out playing on Human mode while using the following guides.

Every Item in Each Level
Secret Mission Guide

Step #2: The Long Haul
So, you've maxed out your health and devil trigger, and know a thing or two about the game? Now it's time for the nightmare, S-ranking every level on every difficulty.

S-Rank Requirements

Your best bet would be to start on another Human run and working your way up until you get to the big one, Dante Must Die. By the time you unlock Dante Must Die, you should have a very good idea of what you need to do. Make sure, you go in prepared, having as many items on hand as you can, as you will go through them very quickly. If possible, try to get the Item Collector achievement before starting DMD.

Step #3: Loose Ends
If you were able to finish DMD, you have my respect. Once you've finished it, all you have left is the Heaven or Hell, Hell or Hell, grinding, and the Bloody Palace. Start by going through Heaven or Hell, and then Hell or Hell. Thanks to the super characters you've unlocked from DMD, it won't take to long to finish both modes. Make sure you don't use the super characters to S-rank any levels you haven't already, as using a super characters makes it impossible to do so.

After that's done, it's time for one final challenge, the Bloody Palace. It's not nearly as hard as DMD, but don't relax just yet. Take the time to prepare for it before hand, and remember, take your time, you don't want to have to restart if you make a mistake. Also, don't use a super character here either, as it will also void your chance of S-ranking it.

Bloody Palace Guide

Upon finishing the BP, you may or may not be done with game. If you aren't, then it's time to start grinding. More than likely, you only need a few more kills and proud souls. If you still need both, another run of the Bloody Palace is your best bet.

Conclusion
If you're still having trouble with anything, you might want to try looking at Youtube, as there are quite a few S-rank run videos there. Even if you're not as good as the people there, imitating their strategies help out a lot. For anyone even trying to max this game out, I wish you the best of luck, as there will be much blood, sweat, and tears.