Enchanted an item.
Runes are separated into two categories: weapon runes and armor runes. Your first opportunity to begin crafting runes comes when you meet a vendor upon your arrival to Kirkwall. These runes will require particular ingredients in order to be crafted. Once you have the rune in your possession, you must find an Enchanter! (See what I did there?) The enchanter can be found in Hightown during Act I, the Deep Roads during the Expedition and your estate from Act II onward.